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igfbp3 specific sirna  (MedChemExpress)


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    MedChemExpress igfbp3 specific sirna
    Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of <t>IGFBP3</t> and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h
    Igfbp3 Specific Sirna, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/igfbp3+specific+sirna/pmc12903644-176-0-6?v=MedChemExpress
    Average 93 stars, based on 2 article reviews
    igfbp3 specific sirna - by Bioz Stars, 2026-08
    93/100 stars

    Images

    1) Product Images from "Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma"

    Article Title: Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma

    Journal: Journal of Translational Medicine

    doi: 10.1186/s12967-025-07606-9

    Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of IGFBP3 and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h
    Figure Legend Snippet: Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of IGFBP3 and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h

    Techniques Used: Quantitative RT-PCR, Biomarker Discovery, Gene Expression

    IGFBP3 expression positively correlates with VEGFA and regulates meningioma cell viability and migration. (A–B) Correlation of IGFBP3 and NDRG1 expression with VEGFA in meningioma patients. ( C ) RT-qPCR validation of IGFBP3 across tumor grades and recurrent vs. non-recurrent cases. (D) Confirmation of IGFBP3 downregulation at the protein level upon IGFBP3 siRNA transfection via western blotting ( n = 2) ( E ) IGFBP3 depletion reduces meningioma cell viability. ( F-G ) Wound-healing assay showing reduced migration upon IGFBP3 silencing
    Figure Legend Snippet: IGFBP3 expression positively correlates with VEGFA and regulates meningioma cell viability and migration. (A–B) Correlation of IGFBP3 and NDRG1 expression with VEGFA in meningioma patients. ( C ) RT-qPCR validation of IGFBP3 across tumor grades and recurrent vs. non-recurrent cases. (D) Confirmation of IGFBP3 downregulation at the protein level upon IGFBP3 siRNA transfection via western blotting ( n = 2) ( E ) IGFBP3 depletion reduces meningioma cell viability. ( F-G ) Wound-healing assay showing reduced migration upon IGFBP3 silencing

    Techniques Used: Expressing, Migration, Quantitative RT-PCR, Biomarker Discovery, Transfection, Western Blot, Wound Healing Assay



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    igfbp3 specific sirna  (MedChemExpress)
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    MedChemExpress igfbp3 specific sirna
    Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of <t>IGFBP3</t> and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h
    Igfbp3 Specific Sirna, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
    igfbp3 specific sirna - by Bioz Stars, 2026-08
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    Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of <t>IGFBP3</t> and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h
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    Image Search Results


    Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of IGFBP3 and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h

    Journal: Journal of Translational Medicine

    Article Title: Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma

    doi: 10.1186/s12967-025-07606-9

    Figure Lengend Snippet: Hypoxia-responsive gene signatures identified in grade 3 meningioma. ( A ) Significant differentially expressed genes in hypoxic versus normoxic IOMM-Lee cells; volcano plot depicting the upregulated and downregulated genes under Hypoxic versus Normoxic conditions in IOMM-Lee (Grade 3 Meningioma cell line). ( B ) Cluster heatmap of DEGs showing top 25 upregulated and downregulated genes. The color transition from blue to red indicates a change from downregulation to upregulation. ( C , D ) RT-qPCR validation of gene expression changes at 6, 24, 48 h under hypoxic conditions (0.2% O₂). (*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001). ( E , F ) Upregulation of IGFBP3 and NDRG1 at protein level under hypoxia (0.2% O₂) at 48 h

    Article Snippet: IGFBP3 specific siRNA was purchased from MedChemExpress (Cat. No. HY-RS06626, pre-designed siRNA).

    Techniques: Quantitative RT-PCR, Biomarker Discovery, Gene Expression

    IGFBP3 expression positively correlates with VEGFA and regulates meningioma cell viability and migration. (A–B) Correlation of IGFBP3 and NDRG1 expression with VEGFA in meningioma patients. ( C ) RT-qPCR validation of IGFBP3 across tumor grades and recurrent vs. non-recurrent cases. (D) Confirmation of IGFBP3 downregulation at the protein level upon IGFBP3 siRNA transfection via western blotting ( n = 2) ( E ) IGFBP3 depletion reduces meningioma cell viability. ( F-G ) Wound-healing assay showing reduced migration upon IGFBP3 silencing

    Journal: Journal of Translational Medicine

    Article Title: Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma

    doi: 10.1186/s12967-025-07606-9

    Figure Lengend Snippet: IGFBP3 expression positively correlates with VEGFA and regulates meningioma cell viability and migration. (A–B) Correlation of IGFBP3 and NDRG1 expression with VEGFA in meningioma patients. ( C ) RT-qPCR validation of IGFBP3 across tumor grades and recurrent vs. non-recurrent cases. (D) Confirmation of IGFBP3 downregulation at the protein level upon IGFBP3 siRNA transfection via western blotting ( n = 2) ( E ) IGFBP3 depletion reduces meningioma cell viability. ( F-G ) Wound-healing assay showing reduced migration upon IGFBP3 silencing

    Article Snippet: IGFBP3 specific siRNA was purchased from MedChemExpress (Cat. No. HY-RS06626, pre-designed siRNA).

    Techniques: Expressing, Migration, Quantitative RT-PCR, Biomarker Discovery, Transfection, Western Blot, Wound Healing Assay